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原文
Light control of the channel protein may represent a new generation of nano-technology tools. In theory, the construction of a nano-devices are not entirely different from the construction of other devices, engineers must design the parts first and then decide how they are assembled together to achieve the established function. However, the construction of nano-devices is the greatest challenge of this scale must be effectivePlug Valves within the design. Fortunately, evolution has successfully resolved numerous engineering challenges, scientists in the world of total protein that gives inspiration to the natural design. University of Michigan and the Netherlands Geni BiOMaDe Technology Center researchers have demonstrated the power of this approach. Ben Feringa explained, MscL of E. coli is a membrane protein, it belongs to the pipeline controlled substances out of cells, in the light of the role it will be reversed to open or shut, in a natural system, this is a safe the valve. He said: "It can prevent the cells burst, if excessive pressure within the cell, the channel will be open 3-nm pores, many things will go out, so it is a very good channel, automatically Chang open, the ideal state can control it on and off. " Typically, MscL is always closed due to hydrophobic interactions. However, if there is a considerable load, MscL has been the hole will be forced to open, until the load disappears. Feringa and colleagues designed a reversible optical switch, the charge under the action of Reducing Valves ultraviolet light, and in the discharge under the action of visible light. This switch is attached to MscL monomer special parts, were sent through the transformation of synthesis of membrane proteins. Experimental validation, UV induced channel open, until the effect of visible light to re-close. In the second round of experiments, the researchers will go through the transformation of MscL into micro-lipid body lipids in vivo with fluorescent dye, experiments showed that, in addition to a small amount of leakage outside the body of energy efficient fluorescent lipid regulating agent the release. This is just an initial discovery, researchers are working to improve this approach, they hope that this technique can be applied on controlled drug delivery. Feringa a broader vision, he foresaw the great features of these micro-devices, and believe they can become an essential component of precision nano-devices. He said: "In the field of nanotechnology, we rarely know how to integrate parts, how to assemble them and make them work properly." "When the basic principle is proved, the new challenge is to see how some of this with nano valve nano fluid channels combined exercise of the valve function. "

原文来自：http://www.ballvalve.org.cn Light control valve successfully developed nano-channel protein是由上海一环流体控制设备有限公司提供的阀门新闻，中文译文仅供参考，以下提供站内导航搜索：中国球阀网球阀产品球阀知识球阀厂商球阀博客球阀行业新闻

译文：
光控的蛋白质通道也许代表了一种新一代的纳米技术工具。从理论上讲，建造一个纳米设备并非完全不同于建造其它的设备，工程师第一步设计出必需的部件，然后再决定如何将它们组装起来实现既定功能。然而，建造纳米设备的最大困难是必须在这个尺度内进行有效的设计。幸运的是，进化成功地解决了无数的止回阀工程挑战，科学家在蛋白质的世界里总能发现给人灵感的自然设计。荷兰哥尼根大学和BiOMaDe技术中心的研究人员展示了这种方法的力量。Ben Feringa解释说，MscL是大肠杆菌上的一种膜蛋白，它属于控制物质进出细胞的管道，在光的作用下它会可逆转地开或关，在自然的系统里，这就是一种安全阀。

他说：“它能防止细胞爆裂，如果细胞内的压力过大，通道的小孔就会张开3个纳米，许多东西就会流出去。因此，它是一个非常好的通道，能自动张开的、理想的状态能控制它的开和关。” 通常情况下，MscL因疏水作用总是紧闭的。但是，如果有相当的负荷，MscL的小孔就会被迫一直张开，直到负荷消失。Feringa和同事设计了一种可逆转的光开关，在紫外光的作用下会充电，而在可见光的作用下会放电。这种开关附着在MscL单体的特殊部位，经过改造的蛋白质被送进合成膜。实验确证，紫外光能诱导通道的张开，直至在可见光的作用下重新合上。在第二轮的实验中，研究人员将经过改造的MscL注入微脂质体内，脂质体内含有荧光染剂，疏水阀实验显示，除了少量的泄漏以外，光能有效地调节脂质体内的荧光染剂的释放。

这只是一个最初的发现，研究人员们正在改进这种方法，他们希望这种技术能应用于可控的药物输送上。Feringa有更远大的目标，他预见了这些微型设备的巨大功能，并相信它们能够成为精密纳米设备的基本构件。他说：“在纳米技术领域，我们很少知道如何整合零件、如何组装它们并让它们恰当地工作。”“当基本原理被证明后，新的挑战就是看看如何将这种纳米阀与部分纳米流体通道结合起来，行使阀门的功能。”

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